LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9457986
rs9457986
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		T 0.700 GeneticVariation GWASCAT Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study. 26377243 2015
dbSNP: rs9457986
rs9457986
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		C 0.700 GeneticVariation GWASCAT Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study. 26377243 2015
dbSNP: rs9365169
rs9365169
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		G 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs9364559
rs9364559
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE Results of haplotype analysis showed that 4 haplotypes which contained rs9364559-G were associated with increased risk of CAD in this population. 24790998 2014
dbSNP: rs9355814
rs9355814
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		T 0.700 GeneticVariation GWASCAT Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study. 26377243 2015
dbSNP: rs9355296
rs9355296
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs9355296
rs9355296
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs7770628
rs7770628
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		C 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs7770628
rs7770628
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		C 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs7770628
rs7770628
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		C 0.700 GeneticVariation GWASCAT A genome-wide association study on lipoprotein (a) levels and coronary artery disease severity in a Chinese population. 31186284 2019
dbSNP: rs7767084
rs7767084
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0010068
Disease:
Coronary heart disease 		0.710 GeneticVariation BEFREE However, our meta-analysis indicated that rs7767084</span> is not associated with a higher ri</span>sk of CHD. 23653095 2013
dbSNP: rs7767084
rs7767084
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		0.710 GeneticVariation BEFREE Using a Chinese Han sample, which consisted of 1012 well-characterized CAD patients and 889 healthy controls, we tested the associations of four SNPs (rs2048327, rs3127599, rs7767084 and rs10755578) in the SLC22A3-LPAL2-LPA gene cluster, and their inferred haplotypes with the risk of CAD. 23036009 2012
dbSNP: rs7767084
rs7767084
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0010068
Disease:
Coronary heart disease 		T 0.710 GeneticVariation GWASCAT Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. 19198611 2009
dbSNP: rs7767084
rs7767084
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		0.710 GeneticVariation GWASDB Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. 19198611 2009
dbSNP: rs7765781
rs7765781
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE We herein genotyped four single nucleotide polymorphisms (SNPs) in lipid metabolism-related genes (rs1132899 and rs5167 in APOC4, rs1801693 and rs7765781 in LPA), aimed to shed light on the influence of these SNPs on individual susceptibility to early-onset CAD. 26129832 2015
dbSNP: rs7759633
rs7759633
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0202236
Disease:
Triglycerides measurement 		G 0.700 GeneticVariation GWASCAT The impact of low-frequency and rare variants on lipid levels. 25961943 2015
dbSNP: rs7755463
rs7755463
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs76000021
rs76000021
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		C 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs75692336
rs75692336
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		A 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs75234242
rs75234242
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1096202
Disease:
Lipoprotein (a) measurement 		A 0.700 GeneticVariation GWASCAT A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. 28512139 2017
dbSNP: rs74617384
rs74617384
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		0.710 GeneticVariation BEFREE We found genome-wide significant evidence for association with CAD at the previously well-established LPA locus (lead variant: rs74617384; OR 1.38 [95% CI 1.26, 1.51], p = 3.2 × 10<sup>-12</sup>) and at 9p21 (lead variant: rs10811652; OR 1.19 [95% CI 1.13, 1.26], p = 6.0 × 10<sup>-11</sup>). 30003307 2018
dbSNP: rs74617384
rs74617384
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1956346
Disease:
Coronary Artery Disease 		T 0.710 GeneticVariation GWASCAT We found genome-wide significant evidence for association with CAD at the previously well-established LPA locus (lead variant: rs74617384; OR 1.38 [95% CI 1.26, 1.51], p = 3.2 × 10<sup>-12</sup>) and at 9p21 (lead variant: rs10811652; OR 1.19 [95% CI 1.13, 1.26], p = 6.0 × 10<sup>-11</sup>). 30003307 2018
dbSNP: rs74617384
rs74617384
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0011849
Disease:
Diabetes Mellitus 		T 0.700 GeneticVariation GWASCAT Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank. 30003307 2018
dbSNP: rs74617384
rs74617384
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C1445957
Disease:
Serum total cholesterol measurement 		T 0.700 GeneticVariation GWASCAT Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. 28270201 2017
dbSNP: rs74617384
rs74617384
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0011847
Disease:
Diabetes 		T 0.700 GeneticVariation GWASCAT Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank. 30003307 2018